Orchestrated trafficking and activation by pathogen‐derived peptides define the ability of CD 4⁺ T helper cells to contribute to an effective adaptive immunity. In this issue of The EMBO Journal , Martín‐Leal et al show that the inflammatory chemokine receptor CCR 5, well known for its role in cell migration and HIV infection, regulates ceramide synthesis and TCR nanoclustering to promote memory CD 4⁺ T cell activation.

中文翻译：

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CCR5 缺陷/CCR5Δ32：以 CD4+ T 细胞记忆反应减弱为代价抵抗 HIV 感染。


病原体衍生肽的精心安排的运输和激活定义了 CD 4 ⁺ T 辅助细胞促进有效适应性免疫的能力。在本期《EMBO 杂志》中，Martín-Leal等人表明，炎症趋化因子受体 CCR 5（以其在细胞迁移和 HIV 感染中的作用而闻名）调节神经酰胺合成和 TCR 纳米簇，以促进记忆 CD 4 ⁺ T 细胞激活。