Background: Aluminum Al(III) is the most significant metal in the earth's crust to which humans are frequently exposed and has several industrial applications. On the other hand, Al (III) has high potential toxic impacts on some human pathologies like Parkinson and Alzheimer's disease. So, it is very important to monitor and determine the trace level of Al (III) in various environmental and biological samples.

Objective: In the present work, a novel green supramolecular Solvent-Based Liquid-Phase Microextraction (SS-LPME) procedure has been developed to preconcentrate and determine aluminum (III) in various real samples.

Methods: The proposed procedure was based on the application of 1-decanol/THF as a Supramolecular Solvent (SS) system and quinalizarin as a chelating agent. Al(III)-quinalizarin hydrophobic complex was obtained at pH 7.0, extracted into supramolecular solvent phase (1- decanol/THF), centrifuged and then measured spectrophotometrically at 580 nm. The impact of different analytical parameters on the microextraction efficiency was studied and optimized. The validation of the proposed preconcentration procedure was checked using certified reference materials.

Results: The calibration curve was linear in the range of 2.0-150 μg L-1. The developed method has preconcentration factor of 40 and detection limit (LOD) was 0.20 μg L-1. The precision of the method was confirmed with low relative standard deviation (RSD ≤ 1.0%).

Conclusion: This study explores the effectiveness of quinalizarin for the first time together with SS to develop green SS-LPME method to preconcentrate and separate trace quantities of Al (III) in real water, fruit juice, food, hair, and urine samples collected from Saudi Arabia.

背景：铝Al（III）是地壳中人类最常接触的最重要的金属，并具有多种工业应用。另一方面，Al（III）对某些人类病理如帕金森氏症和阿尔茨海默氏病具有很高的潜在毒性影响。因此，监测和确定各种环境和生物样品中的痕量Al（III）非常重要。

目的：在目前的工作中，开发了一种新颖的基于绿色超分子溶剂的液相微萃取（SS-LPME）程序，可以对各种真实样品中的铝（III）进行预浓缩和测定。

方法：拟议的程序是基于1-癸醇/ THF作为超分子溶剂（SS）系统和奎那利嗪作为螯合剂的应用。在pH 7.0下获得Al（III）-喹那扎林疏水复合物，萃取到超分子溶剂相（1-癸醇/ THF）中，离心，然后在580 nm处进行分光光度法测量。研究和优化了不同分析参数对微萃取效率的影响。使用认证的参考材料检查了所提出的预浓缩程序的有效性。

结果：校准曲线在2.0-150μgL-1范围内呈线性。所开发的方法的预浓缩系数为40，检测极限（LOD）为0.20μgL-1。相对低的标准偏差（RSD≤1.0％）证实了方法的准确性。

结论：本研究首次探索了奎那利嗪与SS一起开发绿色SS-LPME方法以预浓缩和分离从水中收集的真实水，果汁，食物，头发和尿液中的痕量Al（III）的功效。沙特阿拉伯。