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Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective.
Stem Cells International ( IF 3.8 ) Pub Date : 2020-07-08 , DOI: 10.1155/2020/9836518
Mengyuan Wang 1 , Jiang Xie 2 , Cong Wang 1 , Dingping Zhong 2 , Liang Xie 3 , Hongzhi Fang 1
Affiliation  

Periodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue. The complexity of periodontal tissue and the local inflammatory microenvironment poses great challenges to tissue repair. Recently, stem cells have been considered a promising strategy to treat tissue damage and inflammation because of their remarkable properties, including stemness, proliferation, migration, multilineage differentiation, and immunomodulation. Several varieties of stem cells can potentially be applied to periodontal regeneration, including dental mesenchymal stem cells (DMSCs), nonodontogenic stem cells, and induced pluripotent stem cells (iPSCs). In particular, these stem cells possess extensive immunoregulatory capacities. In periodontitis, these cells can exert anti-inflammatory effects and regenerate the periodontium. Stem cells derived from infected tissue possess typical stem cell characteristics with lower immunogenicity and immunosuppression. Several studies have demonstrated that these cells can also regenerate the periodontium. Furthermore, the interaction of stem cells with the surrounding infected microenvironment is critical to periodontal tissue repair. Though the immunomodulatory capabilities of stem cells are not entirely clarified, they show promise for therapeutic application in periodontitis. Here, we summarize the potential of stem cells for periodontium regeneration in periodontitis and focus on their characteristics and immunomodulatory properties as well as challenges and perspectives.

中文翻译:

牙周炎中干细胞的免疫调节特性:现状和未来展望。

牙周炎是第六种最普遍的慢性炎性疾病,逐渐破坏了牙齿支持组织。牙周组织的复杂性和局部炎性微环境对组织修复提出了巨大挑战。最近,由于干细胞具有非凡的特性,包括干性,增殖,迁移,多谱系分化和免疫调节,因此已被认为是治疗组织损伤和炎症的有前途的策略。几种干细胞可以潜在地应用于牙周再生,包括牙齿间充质干细胞(DMSC),非牙源性干细胞和诱导性多能干细胞(iPSC)。特别地,这些干细胞具有广泛的免疫调节能力。在牙周炎中 这些细胞可以发挥抗炎作用并再生牙周膜。源自感染组织的干细胞具有典型的干细胞特征,具有较低的免疫原性和免疫抑制作用。多项研究表明,这些细胞也可以再生牙周膜。此外,干细胞与周围感染微环境的相互作用对于牙周组织修复至关重要。尽管干细胞的免疫调节功能尚未完全阐明,但它们有望在牙周炎中进行治疗。在这里,我们总结了干细胞在牙周炎中牙周膜再生的潜力,并着重于它们的特征和免疫调节特性以及挑战和观点。源自感染组织的干细胞具有典型的干细胞特征,具有较低的免疫原性和免疫抑制作用。几项研究表明,这些细胞也可以再生牙周膜。此外,干细胞与周围感染的微环境的相互作用对于牙周组织修复至关重要。尽管干细胞的免疫调节功能尚未完全阐明,但它们有望在牙周炎中进行治疗。在这里,我们总结了干细胞在牙周炎中牙周膜再生的潜力,并着重于它们的特征和免疫调节特性以及挑战和观点。源自感染组织的干细胞具有典型的干细胞特征,具有较低的免疫原性和免疫抑制作用。几项研究表明,这些细胞也可以再生牙周膜。此外,干细胞与周围感染的微环境的相互作用对于牙周组织修复至关重要。尽管干细胞的免疫调节功能尚未完全阐明,但它们有望在牙周炎中进行治疗。在这里,我们总结了干细胞在牙周炎中牙周膜再生的潜力,并着重于它们的特征和免疫调节特性以及挑战和观点。此外,干细胞与周围感染的微环境的相互作用对于牙周组织修复至关重要。尽管干细胞的免疫调节功能尚未完全阐明,但它们有望在牙周炎中进行治疗。在这里,我们总结了干细胞在牙周炎中牙周膜再生的潜力,并着重于它们的特征和免疫调节特性以及挑战和观点。此外,干细胞与周围感染的微环境的相互作用对于牙周组织修复至关重要。尽管干细胞的免疫调节功能尚未完全阐明,但它们有望在牙周炎中进行治疗。在这里,我们总结了干细胞在牙周炎中牙周膜再生的潜力,并着重于它们的特征和免疫调节特性以及挑战和观点。
更新日期:2020-07-08
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