In this study, we report two new possible susceptible genes for late-onset Alzheimer's disease identified through an APOE-stratified genome-wide association analysis (GWAS) using East Asian samples. In the discovery phase, we performed a GWAS of Alzheimer's disease in 2,291 Korean seniors from the Gwangju Alzheimer's and Related Dementias (GARD) cohort study. A successive replication analysis with a Japanese sample of size 1,956 suggested three novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants can be accomplished in non-European ethnic groups with a more homogeneous genetic background using samples comprising fewer subjects.

中文翻译：

---

APOE分层的全基因组关联研究表明，在东亚血统中潜在的迟发性阿尔茨海默氏病新基因可能

在这项研究中，我们报告了通过使用东亚样本进行APOE分层的全基因组关联分析（GWAS）鉴定的晚期阿尔茨海默氏病的两个新的易感基因。在发现阶段，我们在光州阿尔茨海默氏症和相关痴呆症（GARD）队列研究中对2,291名韩国老年人进行了阿尔茨海默氏病的GWAS。用日本大小为1,956的样本进行的连续复制分析表明，在两个基因LRIG1和CACNA1A中存在三个新的易感SNP。这项研究表明，与AD相关的变体的发现可以在具有更均一遗传背景的非欧洲族裔群体中使用包含较少受试者的样品来完成。