Noble metal Au nanoparticles have attracted extensive interests in the past decades, due to their size and morphology dependent localized surface plasmon resonances. Their unique optical property, high chemical stability, good biocompatibility, and easy functionalization make them promising candidates for a variety of biomedical applications, including bioimaging, biosensing, and cancer therapy. With the intention of enhancing their optical response in the near infrared window and endowing them with additional magnetic properties, Au nanoparticles have been integrated with other functional nanomaterials that possess complementary attributes, such as copper chalcogenides and magnetic metal oxides. The as constructed hybrid nanostructures are expected to exhibit unconventional properties compared to their separate building units, due to nanoscale interactions between materials with different physicochemical properties, thus broadening the application scope and enhancing the overall performance of the hybrid nanostructures. In this review, we summarize some recent progresses in the design and synthesis of noble metal Au-based hybrid inorganic nanostructures for nanomedicine applications, and the potential and challenges for their clinical translations.

中文翻译：

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用于纳米医学应用的金基无机纳米杂化物。

贵金属Au纳米颗粒由于其尺寸和形态依赖于局部表面等离子体激元共振，因此在过去几十年中引起了广泛的关注。它们独特的光学性能，高化学稳定性，良好的生物相容性和易于功能化使其成为各种生物医学应用（包括生物成像，生物传感和癌症治疗）的有希望的候选者。为了增强其在近红外窗口中的光学响应并赋予其附加的磁性，Au纳米颗粒已与具有互补属性的其他功能纳米材料（例如硫族铜和磁性金属氧化物）整合在一起。与单独的建筑单元相比，这种混合纳米结构有望表现出非常规的性能，由于具有不同物理化学性质的材料之间的纳米级相互作用，因此拓宽了应用范围并增强了杂化纳米结构的整体性能。在这篇综述中，我们总结了用于纳米医学应用的贵金属金基杂化无机纳米结构的设计和合成的一些最新进展，以及其临床翻译的潜力和挑战。