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Metal-Catalyzed Carbon-Carbon Bond Cleavage of Unstrained Alcohols.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-07-08 , DOI: 10.1021/acs.chemrev.0c00154 Marius D R Lutz 1 , Bill Morandi 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-07-08 , DOI: 10.1021/acs.chemrev.0c00154 Marius D R Lutz 1 , Bill Morandi 1
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The functionalization of molecules by cleaving inert carbon–carbon single bonds is regarded as a great synthetic challenge due to their inherent stability. In recent years, significant progress has been made in the activation of small rings relying on the release of strain energy. By contrast, the number of catalytic methodologies for the activation of unstrained carbon–carbon single bonds is still limited. This review focuses on the recent developments in transition-metal-catalyzed cleavage of C–C bonds in unstrained alcohols via β-carbon elimination. Emphasis is placed on the mechanistic aspects of the discussed transformations and their applications to the deconstruction and reorganization of molecules.
中文翻译：
金属催化的无应变醇的碳-碳键裂解。
通过裂解惰性碳-碳单键使分子功能化，由于其固有的稳定性，被认为是一个巨大的合成挑战。近年来，依靠应变能的释放在小环的活化方面取得了重大进展。相比之下，用于激活未应变碳-碳单键的催化方法的数量仍然有限。这篇综述着重于过渡金属催化的通过β-碳消除在未过滤的醇中CC键断裂的最新进展。重点放在讨论的转换的机械方面及其在分子的解构和重组中的应用。
更新日期：2020-07-08
中文翻译：
金属催化的无应变醇的碳-碳键裂解。
通过裂解惰性碳-碳单键使分子功能化，由于其固有的稳定性，被认为是一个巨大的合成挑战。近年来，依靠应变能的释放在小环的活化方面取得了重大进展。相比之下，用于激活未应变碳-碳单键的催化方法的数量仍然有限。这篇综述着重于过渡金属催化的通过β-碳消除在未过滤的醇中CC键断裂的最新进展。重点放在讨论的转换的机械方面及其在分子的解构和重组中的应用。
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