MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target mRNAs at the post-transcriptional level. Increasing evidence shows the involvement of miRNAs in diverse biological processes. miR-302/367 cluster is highly conserved among vertebrates and made up of five members, including miR-367, miR-302a, miR-302b, miR-302c and miR-302d. miR-302/367 cluster plays an important role in cell proliferation, differentiation and reprogramming, affecting the development of tumor, cardiovascular system, nervous system and immune system. In this review, we will summarize the role of miR-302/367 cluster in embryonic stem cells and induced pluripotent stem cells and try to point out its relationship with tumors, cardiovascular system, nervous system and immune system.

中文翻译：

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miR-302 / 367簇在人类生理和病理生理中的作用。

MicroRNA（miRNA）是小的非编码RNA，可在转录后水平上负调控靶mRNA。越来越多的证据表明miRNA参与了多种生物过程。miR-302 / 367簇在脊椎动物中高度保守，由五个成员组成，包括miR-367，miR-302a，miR-302b，miR-302c和miR-302d。miR-302 / 367簇在细胞增殖，分化和重编程中起重要作用，影响肿瘤，心血管系统，神经系统和免疫系统的发育。在这篇综述中，我们将总结miR-302 / 367簇在胚胎干细胞和诱导多能干细胞中的作用，并试图指出其与肿瘤，心血管系统，神经系统和免疫系统的关系。