In Indonesia, BCG protection against M. tuberculosis infection decreased with increasing exposure to the pathogen. We aimed to validate these findings in Africa. Poisson regression was used to estimate BCG protection, stratified by exposure using an exposure score, against ELISPOT conversion at 3 months in 220 Gambian case contacts. While the interaction between BCG and exposure was not significant (p=0.13), BCG protection was strongest in the lowest exposure tertile (RR, 0.35 [95% CI,0.15-0.82]; P=0.02), and the RRs for the middle and highest tertile were 0.50 (0.30-0.83; P=0.008) and 0.71 (0.45-1.13; P=0.1) respectively. These results are consistent with those from Indonesia.

中文翻译：

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在冈比亚，BCG 通过暴露水平对结核分枝杆菌感染的保护作用。

在印度尼西亚，卡介苗对结核分枝杆菌感染的保护随着接触病原体的增加而降低。我们的目标是在非洲验证这些发现。Poisson 回归用于估计 BCG 保护，根据暴露评分使用暴露评分进行分层，针对 3 个月时 220 名冈比亚病例接触者的 ELISPOT 转换。虽然 BCG 和暴露之间的相互作用不显着（p = 0.13），但 BCG 保护在最低暴露三分位数中最强（RR，0.35 [95% CI，0.15-0.82]；P = 0.02），中间的 RRs和最高三分位数分别为 0.50 (0.30-0.83; P =0.008) 和 0.71 (0.45-1.13; P =0.1)。这些结果与印度尼西亚的结果一致。