The aim of this work was to study the epidemiology of candidemia in our hospital in order to determine whether the T2MR system might be a useful tool for early diagnosis of candidemia in selected units. We perform a retrospective review of all candidemia episodes registered in the last 12 years in selected units of our hospital in adult and pediatric patients. Candida species and antifungal susceptibility patterns were registered. A total of 686 isolates were registered, of which 625 were infections due to the five most common species of Candida. C. albicans (45.6%) and C. parapsilosis (33.1%) were the predominant species found in our institution. In adults these species were closely followed by C. glabrata (12–21%) in all units. While in pediatric medical and intensive care units (PICU), these species were followed by other uncommon yeasts. Resistance rates to triazoles were low in C. albicans and C. parapsilosis. In C. glabrata and C. tropicalis the resistance rates to fluconazole ranged from 10.86 to 6.67%. Resistance rates for echinocandins were very low and all strains were susceptible to amphotericin B. T2Candida^® might be useful to guide antifungal targeted treatment and discontinuation of antifungal empirical treatment in those units where the five most common Candida species represent more than the ninety percent of the isolates. The selection of medical and surgical units should be based on local epidemiology and antifungal susceptibility patterns. Incidence should be taken into account in order to make clinical decisions based on negative results.

中文翻译：

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西班牙三级医院血流念珠菌属的流行病学作为实施 T2MR (T2CANDIDA®) 以快速诊断念珠菌血症的指南

这项工作的目的是研究我院念珠菌血症的流行病学，以确定 T2MR 系统是否可能成为选定单位早期诊断念珠菌血症的有用工具。我们对过去 12 年在我们医院选定单位的成人和儿童患者中登记的所有念珠菌血症事件进行了回顾性审查。登记了念珠菌种类和抗真菌药敏模式。共登记了 686 株分离株，其中 625 株是由五种最常见的念珠菌引起的感染。白色念珠菌(45.6%) 和近平滑念珠菌(33.1%) 是我们机构中发现的主要物种。在成虫中，这些物种紧随其后的是C. glabrata(12–21%) 在所有单位。在儿科医疗和重症监护病房 (PICU) 中，这些物种之后是其他不常见的酵母菌。白色念珠菌和近平滑念珠菌对三唑类药物的耐药率较低。在光滑念珠菌和热带念珠菌中，对氟康唑的耐药率在 10.86% 到 6.67% 之间。棘白菌素的耐药率非常低，所有菌株都对两性霉素 B 敏感。 T2Candida ^®可能有助于指导抗真菌靶向治疗和停止抗真菌经验性治疗的那些单位，其中五种最常见的念珠菌种占分离株的 90% 以上。内科和外科单位的选择应基于当地的流行病学和抗真菌药敏模式。应考虑发生率，以便根据阴性结果做出临床决策。