Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8–14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings.

医护人员 (HCW) 是从患者或其他医护人员那里感染 SARS-CoV-2 的高危人群。本研究旨在估计西班牙一家大型医院随机抽取的医务人员样本中 SARS-CoV-2 的血清阳性率。在 2020 年 3 月 28 日至 4 月 9 日招募的 578 名参与者中，有 54 名（9.3%，95% CI：7.1-12.0）的 SARS-CoV-2 IgM 和/或 IgG 和/或 IgA 血清呈阳性。 SARS-CoV-2 感染的累积患病率（存在抗体或过去或当前 rRT-PCR 阳性）为 11.2%（65/578，95% CI：8.8–14.1）。在有过去或当前感染证据的人中，40.0% (26/65) 之前未诊断出患有 COVID-19。在此，我们报告了西班牙 COVID-19 疫情高峰期医护人员中抗体血清阳性率相对较低的情况。很大一部分过去或现在感染过的医护人员之前并未被诊断出患有 COVID-19，这需要在医院环境中进行积极的定期 rRT-PCR 检测。