Cucurbit[7]uril-Capped Hybrid Conjugated Oligomer-Gold Nanoparticles for Combined Photodynamic-Photothermal Therapy and Cellular Imaging,ACS Applied Polymer Materials

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Cucurbit[7]uril-Capped Hybrid Conjugated Oligomer-Gold Nanoparticles for Combined Photodynamic-Photothermal Therapy and Cellular Imaging
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-07-07 , DOI: 10.1021/acsapm.0c00540
Melis Özkan ₁ , Seyed Ehsan Hadi ₁ , İlknur Tunç ₂ , Yakup Midilli ₁ , Bülend Ortaç ₁ , Dönüs Tuncel _{1,

3}

Affiliation

Herein, hybrid nanoparticles composed of a red-emitting conjugated oligomer (COL) and gold nanoparticles (Au-NPs) were prepared through a one-pot synthetic method in which the oligomer acts as a reducing agent as well as a matrix to wrap the newly formed Au nanoparticles. These hybrid nanoparticles (COL-Au-NPs) exhibited photodynamic and photothermal activity against both Gram-positive and Gram-negative bacterial strains. They were also proven to possess high photostability and thermal reversibility. Dark cytotoxicity of COL-Au-NPs toward pathogens and mammalian breast cancer cells (MCF-7) reduced significantly upon complexation with cucurbit[7]uril while preserving their light-induced cytotoxic activity when irradiated with a 915 nm laser for photothermal therapy and white light for photodynamic therapy, respectively. Furthermore, these nanoparticles have cellular imaging capability because of their intrinsic fluorescence characteristics and can be used in image-guided therapy.

中文翻译：

葫芦[7]尿嘧啶封端的杂化共轭低聚物-金纳米粒子的光动力-光热疗法和细胞成像相结合。

在此，通过一锅合成法制备了由发射红色共轭低聚物（COL）和金纳米颗粒（Au-NPs）组成的杂化纳米颗粒，其中低聚物充当还原剂以及基质以包裹新的形成金纳米粒子。这些杂化纳米粒子（COL-Au-NPs）对革兰氏阳性和革兰氏阴性细菌菌株均表现出光动力和光热活性。他们还被证明具有很高的光稳定性和热可逆性。与葫芦[7]尿嘧啶络合后，COL-Au-NPs对病原体和哺乳动物乳腺癌细胞（MCF-7）的暗细胞毒性显着降低，同时在用915 nm激光进行光热疗法和白色照射时保留了它们的光诱导细胞毒性活性。光分别用于光动力疗法。此外，

更新日期：2020-09-11

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