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A marine photosynthetic microbial cell factory as a platform for spider silk production.
Communications Biology ( IF 5.2 ) Pub Date : 2020-07-08 , DOI: 10.1038/s42003-020-1099-6
Choon Pin Foong 1, 2 , Mieko Higuchi-Takeuchi 1 , Ali D Malay 1 , Nur Alia Oktaviani 1 , Chonprakun Thagun 1 , Keiji Numata 1, 2
Affiliation  

Photosynthetic microorganisms such as cyanobacteria, purple bacteria and microalgae have attracted great interest as promising platforms for economical and sustainable production of bioenergy, biochemicals, and biopolymers. Here, we demonstrate heterotrophic production of spider dragline silk proteins, major ampullate spidroins (MaSp), in a marine photosynthetic purple bacterium, Rhodovulum sulfidophilum, under both photoheterotrophic and photoautotrophic growth conditions. Spider silk is a biodegradable and biocompatible material with remarkable mechanical properties. R. sulfidophilum grow by utilizing abundant and renewable nonfood bioresources such as seawater, sunlight, and gaseous CO2 and N2, thus making this photosynthetic microbial cell factory a promising green and sustainable production platform for proteins and biopolymers, including spider silks.



中文翻译:

一家海洋光合微生物细胞工厂,作为蜘蛛丝生产的平台。

作为蓝藻,紫色细菌和微藻类的光合微生物,作为经济,可持续地生产生物能源,生化试剂和生物聚合物的有前途的平台,引起了人们的极大兴趣。在这里,我们展示了在海洋光合作用紫色细菌Rhodovulum sulfidophilum中,在光异养和光养养生长条件下,蜘蛛牵引索丝蛋白,主要壶腹spidroins(MaSp)的异养生产。蜘蛛丝是具有出色机械性能的可生物降解和生物相容性材料。嗜硫罗非鱼通过利用丰富和可再生的非食物生物资源(例如海水,阳光,气态CO 2和N 2)生长,从而使这个光合作用微生物细胞工厂成为有前景的绿色且可持续的蛋白质和生物聚合物(包括蜘蛛丝)生产平台。

更新日期:2020-07-08
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