This study investigated the application of crude methanol extract (CME) of Zapoteca portoricensis root and its methanol (MF) and ethyl acetate (EAF) fractions in managing benign prostatic hyperplasia (BPH). Forty-five albino rats (180-200 g) were divided into nine groups of five rats each: Group 1 served as normal control. BPH was induced in groups 2–9 using dihydrotestosterone and estradiol. Group 2 served as BPH-control and group 3 was dutasteride-treated. Groups 4 and 5, 6 and 7, and 8 and 9 were respectively treated with 200 and 400 mg/kg/d b.w. of CME, 200 and 400 mg/kg/d b.w. of MF, and 200 and 400 mg/kg/d b.w. of EAF, respectively for 14 days orally. The effects of the extracts on the hematological and biochemical indices of the rats were assessed. At 400 mg/kg/d b.w, p.o. using a gavage, CME, MF and EAF decreased prostatic specific antigen by 55.91%, 57.54% and 56.75%, respectively comparable to 58.80% by dutasteride (an indication of improved prostate status). The extracts also restored BPH-modified hematological and biochemical status of BPH-induced-extracts-treated rats compared to BPH-control. These findings suggest that Z. portoricensis root extracts normalize aberrations associated with BPH and may justify the plant’s folkloric use in the management of BPH.

本研究调查了Zapoteca portoricensis根的粗甲醇提取物（CME）及其甲醇（MF）和乙酸乙酯（EAF）馏分在处理良性前列腺增生（BPH）中的应用。将45只白化病大鼠（180-200 g）分为9组，每组5只大鼠：第1组作为正常对照组。使用二氢睾丸激素和雌二醇在2-9组中诱导了BPH。第2组用作BPH对照，第3组用度他雄胺治疗。第4、5、6、7、8和9组分别接受200和400 mg / kg / d bw的CME，200和400 mg / kg / d bw的MF以及200和400 mg / kg / d的治疗体重分别为14天，连续14天。评估提取物对大鼠血液和生化指标的影响。使用管饲法CME以400 mg / kg / d bw的剂量口服 MF和EAF分别使前列腺特异抗原降低55.91％，57.54％和56.75％，而度他雄胺则降低58.80％（表明前列腺状态得到改善）。与BPH对照相比，提取物还恢复了BPH诱导的提取物处理的大鼠的BPH修饰的血液学和生化状态。这些发现表明Z. portoricensis根提取物可使与BPH相关的畸变正常化，并可能证明该植物在BPH管理中的民俗用途是合理的。