ABSTRACT

Introduction

Skeletal muscle-derived stem cells (Sk-MDSCs) are considered promising sources of adult stem cell therapy. Skeletal muscle comprises approximately 40–50% of the total body mass with marked potential for postnatal adaptive response, such as muscle hypertrophy, hyperplasia, atrophy, and regenerative capacity. This strongly suggests that skeletal muscle contains various stem/progenitor cells related to muscle-nerve-vascular tissues, which would support the above postnatal events even in adulthood.

Area covered

The focus of this review is the therapeutic potential of the Sk-MDSCs as an adult stem cell autograft. For this purpose, the validity of cell isolation and purification, tissue reconstitution capacity in vivo after transplantation, comparison of the results of basic mouse and preclinical human studies, potential problematic and beneficial aspects, and effective usage have been discussed following the history of clinical applications.

Expert opinion

Although the clinical application of Sk-MDSCs began as a therapy for the systemic disease of Duchenne muscular dystrophy, here, through the unique local injection method, therapy for severely damaged peripheral nerves, particularly the long-gap nerve transection, has been introduced. The beneficial aspects of the use of Sk-MDSCs as the source of local tissue transplantation therapy have also been discussed.

中文翻译：

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肌肉来源的干细胞的生物医学应用：从工作台到床边。

摘要

介绍

骨骼肌衍生干细胞（Sk-MDSC）被认为是成人干细胞疗法的有希望的来源。骨骼肌约占总体重的40％至50％，具有明显的产后适应性反应潜力，例如肌肉肥大，增生，萎缩和再生能力。这强烈表明骨骼肌含有与肌肉-神经-血管组织相关的各种干/祖细胞，即使在成年期，也将支持上述产后事件。

覆盖面积

这篇综述的重点是作为成人干细胞自体移植的Sk-MDSCs的治疗潜力。为此，根据临床应用的历史，讨论了细胞分离和纯化的有效性，移植后体内的组织重建能力，基本小鼠和临床前人体研究结果的比较，潜在的有问题和有益的方面以及有效用法。 。

专家意见

尽管Sk-MDSC的临床应用开始是针对杜氏肌营养不良症的全身性疾病的治疗方法，但在这里，通过独特的局部注射方法，已经引入了严重受损的周围神经特别是长间隙神经横断的治疗方法。还讨论了使用Sk-MDSCs作为局部组织移植治疗来源的有益方面。