Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferation, suppressive function, and stability. Here we evaluate the role of Tregs in atherosclerosis, their metabolic regulation, and the links between their metabolism and atherosclerosis.

中文翻译：

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动脉粥样硬化中的调节性T细胞代谢。

调节性T细胞（Tregs）能够抑制过度的免疫反应，从而防止自身免疫和慢性炎症。Treg的数量减少和抑制功能受损与动脉粥样硬化的进展，动脉壁的慢性炎性疾病和心血管疾病的主要原因有关。因此，改善Treg数量或功能的治疗策略可能有助于预防动脉粥样硬化疾病的发展。越来越多的证据表明，Tregs的细胞内代谢是其增殖，抑制功能和稳定性的关键调节剂。在这里，我们评估Tregs在动脉粥样硬化中的作用，它们的代谢调节以及它们的代谢与动脉粥样硬化之间的联系。