Plasmonic sensing relies on the interaction between the electromagnetic light wave and free electrons that reside at the interface of two materials, one of them being a metal. Surface plasmon resonance (SPR)‐based biosensing has distinct advantages of providing real‐time and label‐free detection technique that is capable of giving accurate and repeatable results. 2D nanomaterials (graphene and transition metal dichalcogenides [TMDCs] such as MoS₂ and WS₂) have recently gained high popularity in the field of biomedical sciences. Using Biacore commercial SPR machine manufactured by GE Healthcare, the efficacy of various combinations of these materials coated on the plasmonic metal gold (Au) (Au + MoS₂, Au + WS₂, Au + graphene, Au + graphene + MoS₂, and Au + graphene + WS₂) is evaluated, in enhancing the sensitivity of the biosensor as compared with the standard Kretschmann configuration (only Au). Some simulation results are also presented at incident light wavelengths of 633 and 785 nm that are based on the angular interrogation method. To conclude, it is found that the sensitivity in the increasing order is: only Au < Au + MoS₂ < Au + WS₂ ≈ Au + graphene < Au + graphene + MoS₂ < Au + graphene + WS₂.

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二维纳米材料在等离子生物传感中的比较性能评估

等离子感测依赖于电磁波和驻留在两种材料的界面上的自由电子之间的相互作用，其中一种是金属。基于表面等离振子共振（SPR）的生物传感具有提供实时和无标记检测技术的独特优势，该技术能够给出准确和可重复的结果。2D纳米材料（石墨烯和过渡金属二硫化碳[TMDC]，例如MoS ₂和WS ₂）最近在生物医学领域得到了广泛的普及。使用GE Healthcare生产的Biacore商业SPR机，将这些材料的各种组合涂覆在等离子金属金（Au）（Au + MoS ₂，Au + WS ₂与标准Kretschmann配置（仅Au）相比，评估了Au +石墨烯，Au +石墨烯+ MoS ₂和Au +石墨烯+ WS ₂），以增强生物传感器的灵敏度。基于角询问法，还给出了在633和785 nm入射光波长下的一些仿真结果。总之，可以发现，以增加顺序的灵敏度是：只有金<金+的MoS ₂  <金+ WS ₂  ≈+的Au石墨烯<金+ +石墨烯的MoS ₂  <金+石墨烯+ WS ₂。