A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of their Estrogenicity.,Molecular Nutrition & Food Research

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A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of their Estrogenicity.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-07-20 , DOI: 10.1002/mnfr.202000289
Luca Dellafiora ₁ , Marco Milioli ₂ , Angela Falco ₂ , Margherita Interlandi ₂ , Abdelrahman Mohamed ₃ , Martin Frotscher ₃ , Benedetta Riccardi ₂ , Paola Puccini ₂ , Daniele Del Rio ₄ , Gianni Galaverna ₁ , Chiara Dall'Asta ₁

Affiliation

Urolithin A and B are gut metabolites of ellagic acid and ellagitannins associated with many beneficial effects. Evidence in vitro pointed to their potential as estrogenic modulators. However, both molecular mechanisms and biological targets involved in such activity are still poorly characterized, preventing a comprehensive understanding of their bioactivity in living organisms. This study aimed at rationally identifying novel biological targets underlying the estrogenic‐modulatory activity of urolithins.

中文翻译：

用于挖掘尿石素 A 和 B 新靶点的硅胶/体外靶标混合捕捞研究：迈向更好地了解其雌激素的一步。

尿石素 A 和 B 是鞣花酸和鞣花单宁的肠道代谢物，具有许多有益作用。体外证据表明它们具有作为雌激素调节剂的潜力。然而，参与这种活动的分子机制和生物靶点仍然缺乏表征，阻碍了对其在生物体中的生物活性的全面了解。本研究旨在合理确定尿石素雌激素调节活性背后的新生物靶点。

更新日期：2020-07-20

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