Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1‐a]isoquinolines derivatives,Journal of Heterocyclic Chemistry

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Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1‐a]isoquinolines derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-08 , DOI: 10.1002/jhet.4091
Seyyed Ali Moghaddas ₁ , Zinatossadat Hossaini ₁ , Daryoush Zareyee ₁

Affiliation

In this study, a new, easy and high yield procedure is investigated for the generation of pyrazine containing pyrrolo[2,1‐a]isoquinoline derivatives using multicomponent reaction of phthalaldehyde or its derivatives, primary amines, α‐haloalketones, electron deficient acetylenic compounds, ammonium acetate and KF/Clinoptilolite nanoparticles (KF/CP NPs) as catalyst in water at room temperature. The reactions of 2‐hydroxy phthalaldehyde, primary amines, α‐haloketones, electron deficient acetylenic compounds, and ammonium acetate in the presence of KF/CP NPs as catalyst in water at room temperature produce pyrazine derivatives in good yields. Also, in this work, antioxidant ability was studied for a number of prepared compounds employing the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and evaluating results with synthetic antioxidants (TBHQ and BHT). Comfortable, simple, fast and fresh procedure is the advantages of this study.

中文翻译：

含吡咯并[2,1-a]异喹啉衍生物的新型吡嗪的绿色合成及其抗氧化能力的研究

在这项研究中，研究了一种新的，简便且高收率的方法，用于生成含吡嗪的吡嗪[2,1- a]异喹啉衍生物，在室温下使用苯甲醛或其衍生物，伯胺，α-卤代酮，缺电子的炔属化合物，乙酸铵和KF /斜发沸石纳米粒子（KF / CP NPs）进行多组分反应作为催化剂。在室温下，在水中存在KF / CP NP作为催化剂的情况下，2-羟基邻苯二甲醛，伯胺，α-卤代酮，缺电子的炔属化合物和乙酸铵在水中的反应生成吡嗪衍生物，收率很高。此外，在这项工作中，还研究了许多制备的化合物的抗氧化能力，这些化合物利用2,2-二苯基-1-吡啶甲基肼基（DPPH）自由基清除能力和化合物的功能来减少三价铁离子实验并评估合成抗氧化剂（TBHQ和BHT）。舒适，简单，

更新日期：2020-07-08

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