The implications of the menstrual cycle for disease susceptibility, development, and severity of acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection are largely unknown. Here, we describe two women infected with SARS‐CoV‐2 whose real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) test results and symptoms changed during the menstrual cycle. The first patient developed a fever on the first day of her menstrual period, and again on the first day of her next menstrual period after hospital discharge. RT‐PCR test results were positive during the first menstrual period before admission, but turned negative during hospitalization, and then were positive again during the second menstrual period after hospital discharge. Another one also developed a fever again on the first day of her menstrual period after hospital discharge. RT‐PCR test results were negative before admission and during hospitalization, but turned positive during the first menstrual period after hospital discharge. The cases indicate sex hormones may play an important role in SARS‐CoV‐2 infection. For women with history of exposure to SARS‐CoV‐2, the management protocol should include assessment of the menstrual status.

中文翻译：

---

感染 SARS-CoV-2 的女性个体在月经周期中 RT-PCR 检测结果和症状的变化：两例报告。

月经周期对急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的疾病易感性、发展和严重程度的影响在很大程度上是未知的。在这里，我们描述了两名感染 SARS-CoV-2 的女性，她们的实时逆转录酶聚合酶链反应 (RT-PCR) 检测结果和症状在月经周期中发生了变化。第一位患者在月经的第一天发烧，出院后的下一个月经的第一天再次发烧。RT-PCR检测结果在入院前第一次月经期间呈阳性，住院期间转为阴性，出院后第二次月经再次呈阳性。另一位患者在出院后经期的第一天也再次发烧。RT-PCR检测结果在入院前和住院期间均为阴性，但在出院后的第一个月经期间转为阳性。这些病例表明性激素可能在 SARS-CoV-2 感染中起重要作用。对于有 SARS-CoV-2 暴露史的女性，管理方案应包括评估月经状况。