Hypoglycemic effect of the fruit extracts of two varieties of Rubus rosifolius.,Journal of Food Biochemistry

当前位置： X-MOL 学术 › J. Food Biochem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hypoglycemic effect of the fruit extracts of two varieties of Rubus rosifolius.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-07 , DOI: 10.1111/jfbc.13365
Theresa F Rambaran ₁ , Nyron Nembhard ₂ , Camille S Bowen-Forbes ₁ , Ruby L Alexander-Lindo ₂

Affiliation

Oral glucose tolerance test on male Sprague–Dawley rats was done to determine the hypoglycemic effect of the n‐hexane, ethyl acetate and methanol fruit extracts (50 mg/kg BW; oral administration) of two varieties of Rubus rosifolius. Metformin was used as a positive control (15 mg/kg BW; intravenous administration). The n‐hexane extract was most potent and was investigated phytochemically to yield compound 1, a mixture of triacylglycerols. In its oxidized state compound 1 produced a significant hypoglycemic effect which was more effective than metformin for the first 30 min of the assay (p = .03) and not significantly different for up to 120 min. Mechanisms through which the oxidized triacylglycerol species could form were explored and presented. This is the first account of the hypoglycemic activity of R. rosifolius and it is also the first account of this activity being credited to compounds other than polyphenols and terpenes in Rubus plants.

中文翻译：

两种红景天果实提取物的降血糖作用。

对雄性Sprague-Dawley大鼠口服葡萄糖耐受性试验是为了确定所述的降血糖作用Ñ己烷，乙酸乙酯和甲醇的水果提取物;的两个品种的（50毫克/千克体重口服给药）空心泡。二甲双胍用作阳性对照（15 mg / kg体重；静脉内给药）。所述Ñ己烷提取物最有效的，并phytochemically研究，得到化合物1，三酰基甘油的混合物。在其氧化状态下，化合物1产生了显着的降血糖作用，在测定的前30分钟内其效果比二甲双胍更有效（p = .03），并且在长达120分钟内没有显着差异。探索并提出了氧化三酰基甘油物质形成的机理。这是关于玫瑰叶红球菌降血糖活性的第一个解释，也是对红宝石植物中多酚和萜烯以外的化合物的这种活性的第一个解释。

更新日期：2020-09-14

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11