Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis,Journal of Neuroimmunology

当前位置： X-MOL 学术 › J. Neuroimmunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jneuroim.2020.577314
Gunnar Houen ₁ , Julie Heiden ₁ , Nicole H Trier ₁ , Anette H Draborg ₂ , Michael E Benros ₃ , Rūta Zinkevičiūtė ₄ , Rasa Petraitytė-Burneikienė ₄ , Evaldas Ciplys ₄ , Rimantas Slibinskas ₄ , Jette L Frederiksen ₅

Affiliation

Antibody indices to Measles, Mumps, Varicella Zoster (MRZ) are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could be extended to increase diagnostic value. Samples from relapsing-remitting (RR) MS and optic neuritis (ON) patients were tested for reactivity to antigens from Epstein-Barr, Varicella Zoster, Measles, Mumps and Rubella (EMMRZ) viruses. Increased IgG levels in serum and cerebrospinal fluid (CSF) were found in RRMS patients, along with a significant correlation between serum and CSF. The sensitivity of the EMMRZ panel was increased approximately 40% compared to the MRZ panel, suggesting that the EMMRZ panel may be useful in MS and ON diagnostics.

中文翻译：

多发性硬化症和视神经炎中的 Epstein-Barr 病毒和嗜神经病毒抗体

麻疹、腮腺炎、水痘带状疱疹 (MRZ) 抗体指数对多发性硬化症 (MS) 具有诊断价值。在这里，我们研究了是否可以扩展该面板以提高诊断价值。测试了复发缓解型 (RR) MS 和视神经炎 (ON) 患者的样本对 Epstein-Barr、水痘带状疱疹、麻疹、腮腺炎和风疹 (EMMRZ) 病毒抗原的反应性。 RRMS 患者的血清和脑脊液 (CSF) 中 IgG 水平升高，且血清和脑脊液 (CSF) 之间存在显着相关性。与 MRZ panel 相比，EMMRZ panel 的灵敏度提高了约 40%，这表明 EMMRZ panel 可用于 MS 和 ON 诊断。

更新日期：2020-09-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11