Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children.,Environmental Research

当前位置： X-MOL 学术 › Environ. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children.
Environmental Research ( IF 7.7 ) Pub Date : 2020-07-08 , DOI: 10.1016/j.envres.2020.109844
Nozomi Tatsuta ₁ , Kunihiko Nakai ₁ , Yuichi Kasanuma ₂ , Miyuki Iwai-Shimada ₃ , Mineshi Sakamoto ₁ , Katsuyuki Murata ₄ , Hiroshi Satoh ₅

Affiliation

Background

Low-level lead exposure during childhood is associated with deficit in child IQ. However, the association between prenatal lead exposure and child IQ remains inconsistent. The objective of our study was to examine the association between prenatal/postnatal lead exposure and child IQ at the age of 12.

Methods

We obtained data pertaining to cord-blood and child-blood lead levels and IQ for 286 children from a prospective birth cohort study (Tohoku Study of Child Development). IQ was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition. Simultaneously, the Boston Naming Test (BNT) was used to assess the children's language ability.

Results

The median lead level in the cord blood was 0.8 μg/dL (5th-95th percentiles, 0.4–1.4 μg/dL), and that in the blood of 12-year-old children was 0.7 μg/dL (0.4–1.1 μg/dL). IQ and BNT scores were significantly lower in boys than in girls; therefore, multiple regression analysis was conducted separately for boys and girls. Among boys, IQ was associated with child-blood lead (B = −16.362, p = 0.033) but not cord-blood lead (B = −6.844, p = 0.309). When boys were divided into four groups according to the child-blood lead levels, there was a significant decreasing trend for IQ. The score with cues of the BNT was associated with both cord-blood (B = −5.893, p = 0.025) and child-blood (B = −7.108, p = 0.022) lead concentrations in boys. Among girls, there was no significant association of the outcomes with cord-blood or child-blood lead level.

Conclusions

These findings suggest that postnatal lead exposure adversely affects the intellectual ability in boys. Furthermore, the language ability is sensitive to prenatal/postnatal lead exposure in boys.

中文翻译：

12岁日本儿童的产前和产后铅暴露和智力发育。

背景

儿童时期低水平的铅暴露与儿童智商不足有关。但是，产前铅暴露与儿童智商之间的关联仍然不一致。我们研究的目的是检查产前/产后铅暴露与12岁儿童智商之间的关系。

方法

我们从一项前瞻性出生队列研究（东北儿童发展研究）中获得了286名儿童的脐带血，儿童血铅水平和智商相关数据。智商使用韦氏儿童智力量表（第四版）进行评估。同时，使用波士顿命名测验（BNT）评估孩子的语言能力。

结果

脐带血中铅水平的中位数为0.8μg/ dL（第5至95个百分位数，0.4-1.4μg/ dL），而12岁儿童血液中铅的中位数水平为0.7μg/ dL（0.4-1.1μg/ d dL）。男孩的智商和BNT分数明显低于女孩；因此，对男孩和女孩分别进行了多元回归分析。在男孩中，智商与儿童血铅有关（B = -16.362，p = 0.033），而与脐血铅无关（B = −6.844，p = 0.309）。当男孩根据儿童血铅水平分为四组时，智商有明显下降的趋势。BNT提示的得分与脐带血（B = −5.893，p = 0.025）和儿童血（B = −7.108，p = 0.022）男孩中的铅浓度。在女孩中，结局与脐带血或儿童血铅水平没有显着相关性。