This study investigated the ability of dual crosslinked interpenetrating polymer network (IPN) blend beads (DIN:SA/PVA-beads), composed of sodium alginate (SA) and poly (vinyl alcohol) (PVA), as a base-triggered carrier for the controlled release of dinotefuran (DIN) in Spodoptera litera midgut. The blend beads were characterized for morphology, encapsulation efficiency, swelling degree, and in vitro release of the blend beads were characterized. The results revealed that the double-crosslinked gel beads had a tightly interpenetrating network structure and exhibited a satisfactory embedding effect for DIN. The maximum of the DIN loading capacity was approximately 1.01%, with a high encapsulation efficiency of 83.19%. The triggered release of DIN from the blend beads was studied in deionized water (pH 3.0–11.0) via high-performance liquid chromatography (HPLC); it was found that the release rate was higher in alkaline pH conditions than in acidic and neutral conditions. An in vivo dynamics and degradation study also demonstrated that the excellent release characteristics of DIN:SA/PVA-beads in the midgut of S. litera. This study provides a promising controlled-release form of dinotefuran that is more effective and can be used for the targeted control of pests with alkaline midgut.

这项研究调查了由海藻酸钠（SA）和聚乙烯醇（PVA）组成的双交联互穿聚合物网络（IPN）混合珠（DIN：SA / PVA-珠）作为碱触发载体的能力斜纹夜蛾中双氯呋喃（DIN）的控制释放中肠。表征共混物珠的形态，包封效率，溶胀度和共混物珠的体外释放。结果表明，双交联的凝胶珠具有紧密的互穿网络结构，并且表现出令人满意的DIN包埋效果。DIN的最大装载量约为1.01％，封装效率高达83.19％。通过去离子水（pH 3.0-11.0）通过高效液相色谱（HPLC）研究了DIN从混合珠粒中的触发释放；发现在碱性pH条件下的释放速率高于在酸性和中性条件下的释放速率。体内动力学和降解研究还表明，DIN：SA / PVA珠粒在中肠中具有出色的释放特性。S.litera。这项研究提供了一种有前途的二呋喃呋喃控释形式，它更有效，可用于碱性中肠害虫的靶向控制。