The presence of mycotoxins in food has created concern. Mycotoxin prevalence in our environment has changed in the last few years maybe due to climatic and other environmental changes. Evidence has emerged from in vitro and in vivo models: some mycotoxins have been found to be potentially carcinogenic, embryogenically harmful, teratogenic, and to generate nephrotoxicity. The risk assessment of exposures to mycotoxins at early life stages became mandatory. In this regard, the effects of toxic compounds on zebrafish have been widely studied, and more recently, mycotoxins have been tested with respect to their effects on developmental and teratogenic effects in this model system, which offers several advantages as it is an inexpensive and an accessible vertebrate model to study developmental toxicity. External post-fertilization and quick maturation make it sensitive to environmental effects and facilitate the detection of endpoints such as morphological deformities, time of hatching, and behavioral responses. Therefore, there is a potential for larval zebrafish to provide new insights into the toxicological effects of mycotoxins. We provide an overview of recent mycotoxin toxicological research in zebrafish embryos and larvae, highlighting its usefulness to toxicology and discuss the strengths and limitations of this model system.

食物中霉菌毒素的存在引起了人们的关注。在过去几年中，我们环境中的霉菌毒素流行率发生了变化，这可能是由于气候和其他环境变化所致。证据已经出现在体外和体内模型：已发现某些霉菌毒素具有潜在致癌性、胚胎危害性、致畸性和肾毒性。在生命早期阶段接触霉菌毒素的风险评估成为强制性的。在这方面，已经广泛研究了有毒化合物对斑马鱼的影响，最近，已经在该模型系统中测试了霉菌毒素对发育和致畸作用的影响，它提供了几个优点，因为它是一种廉价且可用于研究发育毒性的脊椎动物模型。外部受精后和快速成熟使其对环境影响敏感，并有助于检测形态畸形、孵化时间和行为反应等终点。所以，斑马鱼幼虫有可能为真菌毒素的毒理学影响提供新的见解。我们概述了最近在斑马鱼胚胎和幼虫中进行的真菌毒素毒理学研究，强调了其对毒理学的有用性，并讨论了该模型系统的优势和局限性。