The irreversible glycation and oxidation of proteins and lipids produces advanced glycation end products (AGEs). These modified AGEs are triggered to bind the receptor for AGE (RAGE), thereby activating its downstream signaling pathways, such as nuclear factor (NF)-κB and phosphoinositide 3-kinase (PI3K)/Akt, ultimately leading to diabetes and cancers. In this review, we focus on the interaction of AGE–RAGE and their associated pathways. We also consider the activity of phytochemicals, such as genistein and curcumin, that trap dicarbonyl compounds including methylglyoxal (MG) and glyoxalase that arise from multiple pathways to block AGE formation and prevent its interaction with RAGE.

蛋白质和脂质的不可逆糖基化和氧化产生晚期糖基化终产物 (AGEs)。这些修饰的 AGE 被触发以结合 AGE 受体 (RAGE)，从而激活其下游信号通路，如核因子 (NF)-κB 和磷酸肌醇 3-激酶 (PI3K)/Akt，最终导致糖尿病和癌症。在这篇综述中，我们关注 AGE-RAGE 及其相关通路的相互作用。我们还考虑了植物化学物质（如染料木黄酮和姜黄素）的活性，它们捕获二羰基化合物，包括甲基乙二醛 (MG) 和乙二醛酶，这些化合物来自多种途径，以阻止 AGE 形成并防止其与 RAGE 相互作用。