In contrast to other drug-metabolizing cytochrome P₄₅₀ (CYP) oxygenases, CYP2J2 shows considerable extrahepatic activity and is responsible for the olefin epoxidation of several polyunsaturated fatty acid (PUFA) precursors. The resulting epoxylipids act as signaling mediators and show a remarkable variety of biological functions. Recent studies suggest a role of selected CYP2J2-derived epoxylipids and their metabolites in chronic pain, as well as angiogenesis, hematopoiesis, metabolic disorders, and tumor growth. These pleiotropic effects of CYP products imply that targeting CYP2J2 could represent a novel therapeutic strategy in these fields. Here, we explore the biological functions of CYP2J2-derived epoxylipids and discuss therapeutic implications of the CYP2J2 inhibitors that are known so far.

与其他药物代谢细胞色素 P ₄₅₀ (CYP) 加氧酶相比，CYP2J2 显示出相当大的肝外活性，并负责几种多不饱和脂肪酸 (PUFA) 前体的烯烃环氧化。由此产生的环氧脂质充当信号介质并显示出多种不同的生物学功能。最近的研究表明，选定的 CYP2J2 衍生的环氧脂质及其代谢物在慢性疼痛、血管生成、造血、代谢紊乱和肿瘤生长中的作用。CYP 产品的这些多效作用意味着靶向 CYP2J2 可能代表这些领域的新治疗策略。在这里，我们探索了 CYP2J2 衍生的环氧脂质的生物学功能，并讨论了迄今为止已知的 CYP2J2 抑制剂的治疗意义。