COVID-19 is the shocking viral pandemics of this year which affected the health, economy, communications, and all aspects of social activities all over the world. Early diagnosis of this viral disease is very important since it can prevent lots of mortalities and care consumption.

The functional similarities between COVID-19 and COVID-2 in inducing acute respiratory syndrome lightened our mind to find a diagnostic mechanism based on early traces of mitochondrial ROS overproduction as lung cells’ dysfunctions induced by the virus. We designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500 μl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.

COVID-19是今年令人震惊的病毒性大流行，影响了全世界的健康，经济，通讯和社会活动的各个方面。这种病毒性疾病的早期诊断非常重要，因为它可以防止大量死亡和护理消耗。

COVID-19和COVID-2在诱导急性呼吸系统综合症中的功能相似性使我们得以找到一种基于线粒体ROS过量生成的早期痕迹的诊断机制，因为线粒体ROS的过度生成是由病毒引起的肺细胞功能障碍。我们设计了一个简单的电化学传感器来选择性地检测痰液样本中ROS的强度（体积小于500μl）。将传感器的结果与140多个正常病例和涉及病例的临床诊断结果进行比较，得出的响应校准的准确性和敏感性均为97％。在超过4家医院中对传感器进行测试，在基于ROS的痰标本中基于COVID-19的实时追踪中，展示出了希望的光明。