MIL-96 with a controlled size and morphology, was successfully synthesized by an effective new method, in which copper ions were added as a guiding agent. In addition, the introduction of copper improves the conductivity of the material. Compared to traditional methods, this strategy is operationally easy and does not require the addition of large organic molecules in addition to the ligand. Among the series of as-prepared materials, the M_2.5:2.5-based electrochemical aptasensor showed excellent sensitivity with a low limit of detection of 0.12 pg/mL, within a wide linear range of alpha-fetoprotein concentrations from 0.001 to 0.5 ng/mL, with good selectivity, repeatability, stability and applicability in real samples. This work development a new strategy for the controlled synthesis and modification of MOFs. In addition, this work provides a new platform for biosensing, enriching the application field of MOFs.

通过有效的新方法成功合成了尺寸和形态可控的MIL-96，其中添加了铜离子作为导向剂。另外，铜的引入改善了材料的导电性。与传统方法相比，该策略操作简便，除配体外无需添加大型有机分子。在一系列准备好的材料中，M _2.5：2.5的基于电化学的适体传感器显示出优异的灵敏度，在0.001至0.5 ng / mL的甲胎蛋白浓度范围很宽的线性范围内，检出限低至0.12 pg / mL，在真实样品中具有良好的选择性，可重复性，稳定性和适用性。这项工作为MOF的受控合成和修饰开发了一种新策略。此外，这项工作为生物传感提供了一个新的平台，丰富了MOF的应用领域。