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A near-infrared fluorescent probe for H2S based on tandem reaction to construct iminocoumarin-benzothiazole and its application in food, water, living cells
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.aca.2020.06.050 Keli Zhong 1 , Yuqing He 1 , Longlong Deng 1 , Xiaomei Yan 2 , Xuepeng Li 1 , Yiwei Tang 3 , Shuhua Hou 1 , Lijun Tang 1
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.aca.2020.06.050 Keli Zhong 1 , Yuqing He 1 , Longlong Deng 1 , Xiaomei Yan 2 , Xuepeng Li 1 , Yiwei Tang 3 , Shuhua Hou 1 , Lijun Tang 1
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With the merits of non-destructive, high penetration ability and minimizing autofluorescence, near-infrared (NIR) fluorescent probes have attracted much attention. In this paper, a NIR emission fluorescent turn-on probe THQ-L for H2S was synthesized by the knoevenagel condensation between tetrahydroquinoxaline-6- formaldehyde derivative and 2-benzothiazoleacetonitrile. THQ-L can recognize H2S through tandem reaction triggered by HS- to construct 1,4-diethylpiperazine-modified iminocoumarin-benzothiazole, which produces a strong red fluorescent signal. THQ-L displayed an excellent selectivity toward H2S, a large stokes shift (126 nm), a high signal-to-noise ratio (200-fold), the detection limits of 38.3 nM in PBS (10 mM, pH 7.4, 30% THF). The application study indicates that THQ-L can sensitively detect H2S in red wine, natural waters, living cells and can be prepared for a test paper strip for the qualitative detection of H2S.
中文翻译：
基于串联反应构建亚氨基香豆素-苯并噻唑的H2S近红外荧光探针及其在食物、水、活细胞中的应用
近红外（NIR）荧光探针以其无损、高穿透能力和最小自发荧光等优点备受关注。在本文中，通过四氢喹喔啉-6-甲醛衍生物和2-苯并噻唑乙腈之间的knoevenagel 缩合合成了一种用于H2S 的NIR 发射荧光开启探针THQ-L。THQ-L可以通过HS-引发的串联反应识别H2S，构建1,4-二乙基哌嗪修饰的亚氨基香豆素-苯并噻唑，产生强烈的红色荧光信号。THQ-L 显示出对 H2S 的出色选择性、大斯托克斯位移 (126 nm)、高信噪比（200 倍）、在 PBS（10 mM，pH 7.4，30%）中的检测限为 38.3 nM四氢呋喃）。应用研究表明，THQ-L 可以灵敏地检测红酒、天然水、
更新日期：2020-08-01
中文翻译：
基于串联反应构建亚氨基香豆素-苯并噻唑的H2S近红外荧光探针及其在食物、水、活细胞中的应用
近红外（NIR）荧光探针以其无损、高穿透能力和最小自发荧光等优点备受关注。在本文中，通过四氢喹喔啉-6-甲醛衍生物和2-苯并噻唑乙腈之间的knoevenagel 缩合合成了一种用于H2S 的NIR 发射荧光开启探针THQ-L。THQ-L可以通过HS-引发的串联反应识别H2S，构建1,4-二乙基哌嗪修饰的亚氨基香豆素-苯并噻唑，产生强烈的红色荧光信号。THQ-L 显示出对 H2S 的出色选择性、大斯托克斯位移 (126 nm)、高信噪比（200 倍）、在 PBS（10 mM，pH 7.4，30%）中的检测限为 38.3 nM四氢呋喃）。应用研究表明，THQ-L 可以灵敏地检测红酒、天然水、
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