Abstract

The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of SARM traces in various samples. Well-known sample preparation and determination methods in biological materials are considered, and the metabolic pathways the best studied SARM (andarine) using cell cultures (in vitro) and laboratory animals and humans (in vivo) are compared.

中文翻译：

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测定选择性雄激素受体调节剂的方法

摘要

描述了选择性雄激素受体调节剂（SARM）的出现和发展的历史。考虑了SARM的主要类别及其确定方法。色谱-质谱联用法被证明对可靠地测定各种样品中的SARM痕迹很有希望。考虑了生物材料中众所周知的样品制备和测定方法，并比较了使用细胞培养物（体外）和实验室动物及人（体内）对SARM（安达因）进行了研究最好的代谢途径。