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Simultaneous Determination of (2R,3R)-Dihydromyricetin and Myricetin of Mongolia Medicine Sendeng-4 in RAT Plasma by Liquid Chromatography–Mass Spectrometry
Journal of Analytical Chemistry ( IF 1.0 ) Pub Date : 2020-07-07 , DOI: 10.1134/s1061934820070035 Pu Bai , Xin Jia , Yu Dong , Chula Sa , Guoyuan Sun , Xiaoling Zhu
中文翻译:
液相色谱-质谱法同时测定大鼠血浆中蒙古药Sendeng-4的(2R,3R)-二氢杨梅素和杨梅素
更新日期:2020-07-07
Journal of Analytical Chemistry ( IF 1.0 ) Pub Date : 2020-07-07 , DOI: 10.1134/s1061934820070035 Pu Bai , Xin Jia , Yu Dong , Chula Sa , Guoyuan Sun , Xiaoling Zhu
Abstract
A liquid chromatography−mass spectrometry method was developed for the simultaneous quantitation of (2R,3R)-Dihydromyricetin and Myricetin in rat plasma samples to facilitate analysis of samples collected after administration of SenDeng-4 medicine. The plasma was subjected to protein precipitation with HCl (containing 10% ascorbic acid) and analyzed using electrospray ionization mass spectrometry in selected ion monitoring mode with Paeoniflorin as an internal standard. Good linearity for the two compounds was observed. The intra- and inter-day precision of analysis was <10% for each compound. The present method was suitable for determining (2R,3R)-Dihydromyricetin and Myricetin in rat plasma after intravenous administration of SenDeng-4 to rats with sufficient sensitivity.中文翻译:
液相色谱-质谱法同时测定大鼠血浆中蒙古药Sendeng-4的(2R,3R)-二氢杨梅素和杨梅素