To determine the correlation of uric acid (UA) with hemorrhagic transformation (HT) and poor short-term functional outcomes in anterior circulation acute ischemic stroke (AIS) patients after endovascular thrombectomy (EVT). A retrospective analysis was conducted for anterior circulation AIS patients who underwent EVT at our hospital from 2015 to 2019. HT within 72 h was documented according to the European Cooperative Acute Stroke Study II Classification. Baseline demographic, clinical and laboratory data were compared between the HT and non-HT groups, and between patients with favorable and unfavorable outcomes on 90-day. A total of 247 AIS patients were enrolled, of which 92 (37.2%) and 85 (34.4%) experienced HT and had favorable functional outcomes at 3 months respectively. Patients with HT had significantly lower UA levels compared to those without HT (322.60 ± 94.49 vs. 350.25 ± 99.28 μmol /L, P = 0.032). In contrast, UA levels were similar in patients with good or poor outcomes (345.67 ± 103.55 vs. 336.95 ± 95.5 μmol /L, P = 0.509). Compared to the patients with UA levels in the first quartile, those in the fourth quartile were at a higher risk of HT in univariate logistic regression analysis (OR = 0.383, 95% CI = 0.173–0.848, P = 0.018). The association remained significant after multivariable adjustment for potential confounders. A lower UA level is an independent risk factor of HT post-EVT in anterior circulation AIS patients, but is not associated with the short-term functional outcomes.

确定前循环急性缺血性卒中 (AIS) 患者血管内血栓切除术 (EVT) 后尿酸 (UA) 与出血性转化 (HT) 和不良短期功能结果的相关性。对2015年至2019年在我院接受EVT的前循环AIS患者进行回顾性分析。根据欧洲合作急性卒中研究II分类记录72小时内的HT。比较 HT 组和非 HT 组以及 90 天预后良好和不良的患者的基线人口统计学、临床和实验室数据。共有 247 名 AIS 患者入组，其中 92 名（37.2%）和 85 名（34.4%）分别在 3 个月时经历了 HT 和良好的功能结果。P  = 0.032）。相比之下，预后良好或不良的患者的 UA 水平相似（345.67 ± 103.55 vs. 336.95 ± 95.5 μmol /L，P  = 0.509）。与 UA 水平在第一个四分位数的患者相比，在单变量逻辑回归分析中，第四个四分位数的患者发生 HT 的风险更高（OR = 0.383，95% CI = 0.173-0.848，P  = 0.018）。在对潜在混杂因素进行多变量调整后，该关联仍然显着。较低的 UA 水平是前循环 AIS 患者 EVT 后 HT 的独立危险因素，但与短期功能结果无关。