Objective Hypertension is the commonest cause of acute spontaneous intracerebral hemorrhage (ICH) which is life-threatening with a poor prognosis. The aim of this study is to evaluate the prognosis and blood pressure monitoring and control in patients presented by acute spontaneous ICH. Methods One hundred and fifty patients presented by acute spontaneous ICH were classified according to the modified Rankin Scale (mRS) score after discharge to 70 patients with better outcomes (mRS = 0–2) while 80 patients with poor outcome (mRS = 3–6). Independent factors that were significantly related to prognosis were assessed by multivariate logistic regression. Spearman’s correlation of the blood pressure monitoring in the acute ICH and the outcome was investigated. Results Systolic blood pressure at the onset of ICH was higher in the unfavorable outcome group ( P = 0.009). Diastolic blood pressure 1 h after admission, systolic blood pressure 6 h after admission, and the systolic blood pressure 24 h after admission to hospital were lower in the favorable outcome group ( P = 0.005, P = 0.007 and 0.01, respectively). The independent variables related to favorable outcomes were younger age patients ( P = 0.004), better level of consciousness at admission to hospital ( P = 0.0001), and lower systolic blood pressure 6 h after admission to hospital ( P = 0.005), decreased volume of hematoma ( P = 0.05), supratentorial ICH ( P = 0.02), and absence of intraventricular hemorrhage ( P = 0.02). Conclusions Proper control and monitoring of the blood pressure in acute intracerebral hemorrhage must be initiated immediately especially in the first 6 h after hospitalization. Trial registration ClinicalTrials.gov ID: NCT04191863 'Retrospectively registered'

中文翻译：

---

急性自发性脑出血控制高血压和预后的适当时机

目的高血压是急性自发性脑出血（ICH）的最常见原因，可危及生命，预后不良。本研究的目的是评估急性自发性脑出血患者的预后和血压监测和控制。方法 150例急性自发性脑出血患者出院后根据改良Rankin量表（mRS）评分分为70例预后较好（mRS=0~2），80例预后不良（mRS=3~6） ）。通过多变量逻辑回归评估与预后显着相关的独立因素。研究了急性 ICH 中血压监测与结果的 Spearman 相关性。结果 不良结局组 ICH 发作时的收缩压较高（ P = 0.009）。结果良好组患者入院后1 h舒张压、入院6 h收缩压和入院24 h收缩压较低（分别为P = 0.005、P = 0.007和0.01）。与有利结果相关的自变量是年龄较小的患者（ P = 0.004）、入院时意识水平较好（ P = 0.0001）、入院 6 h 后收缩压降低（ P = 0.005）、体积减少血肿 ( P = 0.05)、幕上 ICH ( P = 0.02) 和无脑室内出血 ( P = 0.02)。结论急性脑出血患者必须立即开始适当控制和监测血压，尤其是在住院后的前6小时内。试验注册 ClinicalTrials.gov ID：NCT04191863“回顾性注册”