Background:Levodopa/carbidopa intestinal gel (LCIG) infusion is an efficacious treatment of motor and non-motor fluctuations in people with Parkinson’s disease (PD). Real-life use of the treatment is not previously studied. Objective:The aims of the study were to explore the use of LCIG and to determine how extra doses of LCIG are used in daily life. Methods:Twenty-five PD patients with ongoing LCIG therapy were consecutively included. Pump data was retrieved from 30 days on average, by means of software, extracting the most recent pump events. Results:The daily duration of infusion was 15 hours on average, in 18 patients, whereas the remaining 7 patients used 24-hour infusion. Morning doses ranged from 38–190 mg levodopa, for patients who utilized this function. Median number of daily extra doses was 2.5 (range: 0–10.6) and median size of the extra dose was 24 mg (0–80 mg) levodopa. Median total daily levodopa intake with LCIG was 1201 mg (range: 417–2322 mg). Conclusion:Retrieving pump data is possible and may be important for evaluating the at-home use of LCIG, to optimize the therapy. Adherence to treatment should be monitored, which is not technically difficult, at least in device-aided treatments for PD.

中文翻译：

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根据泵数据分析，左旋多巴/卡比多巴肠凝胶在帕金森病中的实际应用。

背景：左旋多巴/卡比多巴肠凝胶 (LCIG) 输注是治疗帕金森病 (PD) 患者运动和非运动波动的有效方法。以前没有研究过该疗法在现实生活中的使用情况。目的：该研究的目的是探索 LCIG 的使用，并确定如何在日常生活中使用额外剂量的 LCIG。方法：连续纳入 25 名正在进行 LCIG 治疗的 PD 患者。通过软件提取平均 30 天的泵数据，提取最近的泵事件。结果：18例患者的每日输注时间平均为15小时，其余7例患者使用24小时输注。对于使用此功能的患者，早晨剂量范围为 38-190 毫克左旋多巴。每日额外剂量的中位数为 2.5（范围：0-10。6) 额外剂量的中位数为 24 mg (0–80 mg) 左旋多巴。LCIG 的每日左旋多巴总摄入量中位数为 1201 毫克（范围：417-2322 毫克）。结论：检索泵数据是可能的，并且可能对评估 LCIG 的家庭使用情况很重要，以优化治疗。应监测治疗的依从性，这在技术上并不困难，至少在 PD 的器械辅助治疗中是这样。