Background:There is increasing evidence that AD progression differs by sex. Objective:The aim of this work was to determine sex differences in the association of baseline levels of cerebrospinal fluid (CSF) biomarkers (Aβ42, p-tau, YKL-40, sTREM2) with longitudinal brain changes in cognitively unimpaired (CU) older adults. Methods:This pilot study included 36 CU subjects (age 66.5±5.5, 12 male) scanned twice, two years apart. Using a voxel-wise analysis, we determined the sex differences in the association maps between CSF biomarkers and atrophy rates. Results:We did not find differences related to Aβ42. We found a greater impact of the rest of CSF biomarkers in areas of the Papez circuit in women versus men. Men showed greater involvement in lateral parietal and paracentral areas. Discussion:Results suggest an early differential progression of brain atrophy between sexes. Further research will elucidate whether the mechanisms responsible for sex-specific atrophy patterns are biological and/or environmental.

中文翻译：

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认知障碍的成年人纵向脑部变化的性别差异。

背景：越来越多的证据表明，AD进展随性别而异。目的：这项工作的目的是确定认知无障碍（CU）老年人脑脊液（CSF）生物标志物（Aβ42，p-tau，YKL-40，sTREM2）基线水平与纵向脑部变化之间的性别差异。方法：该试验研究包括36位CU受试者（66.5±5.5岁，男性12位），两次扫描，间隔两年。使用体素分析，我们确定了脑脊液生物标志物和萎缩率之间的关联图中的性别差异。结果：我们没有发现与Aβ42有关的差异。我们发现，其余的CSF生物标志物在帕佩兹环路中对女性与男性的影响更大。男性表现出更多的累及顶叶外侧和中央旁区域。讨论：结果表明，男女之间脑萎缩的早期差异发展。进一步的研究将阐明造成性别特异性萎缩模式的机制是生物学的和/或环境的。