Introduction: Many widespread intractable diseases are caused or supported by chronic inflammation. Such conditions include the 2nd type of diabetes mellitus, atherosclerosis, neurodegenerative diseases, chronic inflammatory diseases of the connective tissue - ankylosing spondylitis, rheumatoid arthritis, autoimmune myositis, etc. Therefore, the search for targeted treatment of these illnesses is extremely in high demand. Immunomodulatory activity of mesenchymal stem cells is one of their remarkable properties. Several biomarkers (cytokines and nonspecific proteins) are known to be associated with chronic inflammation.
Methods: Our study aimed to investigate the serum levels of tumor necrosis factor-alpha, interleukin 6 and C-reactive protein in carrageenan myositis in rats, because there is more and more evidence of the significance of these markers in the course and resolution of the diseases mentioned above. For the first time in our experiment, it was shown and evaluated using analysis of variance, how MSCs influence the indicators of proinflammatory cytokines on the model of carrageenan myositis. The levels of α-TNF, IL-6 and CRP in the plasma of rats were studied in groups with chronic carrageenan inflammation and chronic inflammation with local injection of MSCs into the affected area.
Results: Our study proved the effectiveness of MSCs by showing a significant decrease in the levels of inflammatory mediators in the plasma of the studied animals.
Discussion and Conclusions: Thus, the administration of MSCs is a promising tool in the pathogenic treatment of chronic inflammation and concomitant conditions.

Keywords: chronic inflammation, mesenchymal stem cells, carrageenan, tumor necrosis factor-alpha, interleukin-6, C-reactive protein


中文翻译：

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间充质干细胞在大鼠中的抗炎活性：促炎细胞因子。

简介：许多广泛传播的顽固性疾病是由慢性炎症引起或支持的。这些疾病包括第 2 类糖尿病、动脉粥样硬化、神经退行性疾病、结缔组织的慢性炎症性疾病 - 强直性脊柱炎、类风湿性关节炎、自身免疫性肌炎等。因此，寻找针对这些疾病的靶向治疗的需求量很大。间充质干细胞的免疫调节活性是其显着特性之一。已知几种生物标志物（细胞因子和非特异性蛋白质）与慢性炎症有关。
方法：我们的研究旨在调查大鼠卡拉胶肌炎中肿瘤坏死因子-α、白细胞介素6和C反应蛋白的血清水平，因为越来越多的证据表明这些标志物在上述疾病的病程和消退中具有重要意义多于。在我们的实验中，第一次使用方差分析显示和评估了 MSCs 如何影响角叉菜胶肌炎模型上的促炎细胞因子指标。研究了慢性角叉菜胶炎症组和慢性炎症组大鼠血浆中α-TNF、IL-6和CRP的水平，并将MSCs局部注射到患处。
结果：我们的研究通过显示研究动物血浆中炎症介质水平的显着降低证明了 MSCs 的有效性。
讨论和结论：因此，MSCs 的给药是慢性炎症和伴随疾病的致病性治疗的有前途的工具。

关键词：慢性炎症，间充质干细胞，角叉菜胶，肿瘤坏死因子-α，白细胞介素-6，C反应蛋白