A numerical model of drug delivery from a therapeutic lens in the anterior portion of the human eye has been developed for a more effective treatment plan of primary open-angle glaucoma. The numerical model takes into account the drug diffusion through the therapeutic lens along with heat transfer and aqueous humor flow in different orientations of the human eye (supine (two-dimensional) as well as standing (three-dimensional)). Results illustrate that the drug diffuses through the therapeutic lens to the cornea and is convected into the anterior chamber of the eye due to the temperature gradient across the eye. In addition, eye orientation significantly affects drug delivery with supine orientation providing better and uniform drug exposure in different target regions of the eye as compared to standing in the case of the therapeutic lens. Furthermore, a comparison of the therapeutic efficacy of the therapeutic lens has been done with topical administration and the drug uptake results from both the drug delivery modes have been validated with the experimental data reported in the literature. The developed model may help ophthalmologists to comprehend the transport and retention of different drugs in different domains and orientations of the human eye when administered through a therapeutic lens.

已经开发了从人眼前部的治疗晶状体释放药物的数值模型，以制定更有效的原发性开角型青光眼治疗计划。数值模型考虑了药物通过治疗晶状体的扩散以及人眼不同方向（仰卧（二维）和站立（三维））的热传递和房水流动。结果表明，药物通过治疗晶状体扩散到角膜，并由于穿过眼睛的温度梯度而对流进入眼前房。此外，与在治疗性晶状体的情况下站立相比，眼睛方向显着影响药物递送，仰卧方向在眼睛的不同目标区域提供更好和均匀的药物暴露。此外，已经对治疗性晶状体的治疗功效与局部给药进行了比较，并且两种药物递送模式的药物摄取结果已经用文献中报道的实验数据进行了验证。开发的模型可以帮助眼科医生理解通过治疗镜片给药时不同药物在人眼不同区域和方向的转运和保留。