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Solubility Determination and Modeling for Milrinone in Binary Solvent Mixtures of Ethanol, Isopropanol, Ethylene Glycol, and N,N-Dimethylformamide + Water
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-07-07 , DOI: 10.1021/acs.jced.0c00394
Jianqiang Zhang 1 , Xin Song 2 , Renjie Xu 2
Affiliation  

The equilibrium solubility of milrinone in the solvent mixtures of ethanol + water, isopropanol + water, N,N-dimethylformamide (DMF) + water, and ethylene glycol (EG) + water was determined experimentally using the isothermal dissolution equilibrium method within the temperature range from 278.15 to 323.15 K under atmospheric pressure (101.1 kPa). Results show that when the temperature approaches a high level, more drugs can be dissolved in the same amount of solvent. Conversely, when the temperature is close to a low level, the drug is more difficult to dissolve. When the temperature is constant, the proportion of organic solvent is large and the dissolving capacity of the dispersion system develops in a positive direction. Conversely, if the proportion of water is large, the dissolving power of the system will decrease. Milrinone crystals accepted the determination of various dissolution data including undissolved raw materials have undergone X-ray power diffraction (XPRD) detection. The results obtained are encouraging, showing no change in the crystal structure of the substance. Three models, Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and modified Apelblat–Jouyban–Acree model, were employed to calculate the experimental milrinone solubility, and the relative average deviation (RAD) and the root-mean-square deviation (RMSD) were no higher than 1.44% and 8.0 × 10–7, respectively. The research on milrinone gives not only is a simple measurement of the dissolution data but, more importantly, with the support of this data more thermodynamic data can be calculated to obtain milrinone, which is an indispensable link between improving the production process of milrinone and the synthesis of pharmaceutical preparations.

中文翻译:

米力农在乙醇,异丙醇,乙二醇和N,N-二甲基甲酰胺+水的二元溶剂混合物中的溶解度测定和建模

米力农在乙醇+水,异丙醇+水,N,N的溶剂混合物中的平衡溶解度使用等温溶解平衡法在大气压(101.1 kPa)下从278.15至323.15 K的温度范围内,实验测定了-二甲基甲酰胺(DMF)+水和乙二醇(EG)+水。结果表明,当温度接近较高水平时,在相同量的溶剂中可以溶解更多的药物。相反,当温度接近较低水平时,药物更难溶解。当温度恒定时,有机溶剂的比例大,并且分散体系的溶解能力沿正方向发展。相反,如果水的比例大,则系统的溶解能力将降低。Milrinone晶体接受了各种溶解数据的测定,包括未溶解的原材料均经过X射线功率衍射(XPRD)检测。获得的结果令人鼓舞,表明该物质的晶体结构没有变化。三种模型,分别是Jouyban–Acree模型,van't Hoff–Jouyban–Acree模型和改良的Apelblat–Jouyban–Acree模型,用于计算实验性米力农溶解度,相对平均偏差(RAD)和均方根值。平方偏差(RMSD)不高于1.44%和8.0×10–7分别。对米力农的研究不仅给出了溶出度数据的简单测量方法,更重要的是,在该数据的支持下,可以计算出更多的热力学数据以获得米力农,这是改善米力农生产工艺与必不可少的必不可少的联系。药物制剂的合成。
更新日期:2020-08-14
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