Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from various tissues. Due to their regenerative and immunomodulatory properties, MSCs have been extensively researched and tested for treatment of different diseases/indications. One mechanism that MSCs exert functions is through the transfer of mitochondria, a key player involved in many biological processes in health and disease. Mitochondria transfer is bidirectional and has an impact on both donor and recipient cells. In this review, we discussed how MSC-mediated mitochondrial transfer may affect cellular metabolism, survival, proliferation, and differentiation; how this process influences inflammatory processes; and what is the molecular machinery that mediates mitochondrial transfer. In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.

中文翻译：

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间充质干/基质细胞介导的线粒体转移及其在神经疾病治疗中的治疗潜力。

间充质干/基质细胞（MSCs）是多能干细胞，可以衍生自各种组织。由于其再生和免疫调节特性，MSC已被广泛研究和测试以治疗不同疾病/适应症。MSC发挥功能的一种机制是通过线粒体的转移，线粒体是健康和疾病中许多生物过程的关键参与者。线粒体转移是双向的，对供体和受体细胞都有影响。在这篇综述中，我们讨论了MSC介导的线粒体转移如何影响细胞的代谢，存活，增殖和分化。这个过程如何影响炎症过程；介导线粒体转移的分子机制是什么？到底，