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Novel Use of Rifabutin and Rifapentine to Treat Methicillin-Resistant Staphylococcus aureus in a Rat Model of Foreign Body Osteomyelitis.
The Journal of Infectious Diseases ( IF 5.0 ) Pub Date : 2020-07-07 , DOI: 10.1093/infdis/jiaa401
Melissa J Karau 1 , Suzannah M Schmidt-Malan 1 , Mariana Albano 1 , Jayawant N Mandrekar 2 , Christina G Rivera 3 , Douglas R Osmon 4, 5 , Caitlin P Oravec 4 , Daniel J Berry 5 , Matthew P Abdel 5 , Robin Patel 1, 3
Affiliation  

Due to patient intolerance or drug interactions, alternative agents to rifampin are needed for management of staphylococcal periprosthetic joint infection (PJI). Here, we evaluated rifabutin, rifapentine and rifampin, with and without vancomycin, in a rat model of foreign body osteomyelitis.

中文翻译:

利福布汀和利福喷丁在异物骨髓炎大鼠模型中新的用途,用于治疗耐甲氧西林的金黄色葡萄球菌。

由于患者不耐受或药物相互作用,需要使用利福平替代药物来治疗葡萄球菌假体周围关节感染(PJI)。在这里,我们在异体骨髓炎的大鼠模型中评估了利福布汀,利福喷丁和利福平(有或没有万古霉素)。
更新日期:2020-07-07
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