Measles virus (MeV) binds, infects and kills CD150⁺ memory T-cells, leading to “immune amnesia”. Whether MeV targets innate, memory-like T-cells is unknown. We demonstrate that human peripheral blood and hepatic MAIT and iNKT cells express surprisingly high levels of CD150, more than any other lymphocyte subsets, including central and effector memory T-cells. Furthermore, exposing MAIT cells to MeV results in their efficient infection and rapid apoptosis. This constitutes the first report of direct MAIT cell infection by a viral pathogen. Given MAIT cells’ antimicrobial properties, their elimination by MeV may contribute to measles-induced immunosuppression and heightened vulnerability to unrelated infections.

中文翻译：

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麻疹病毒感染并编程 MAIT 细胞的凋亡。

麻疹病毒 (MeV) 结合、感染并杀死 CD150 ⁺记忆 T 细胞，导致“免疫性遗忘症”。MeV 是否针对先天的、类似记忆的 T 细胞尚不清楚。我们证明人外周血和肝脏 MAIT 和i NKT 细胞表达令人惊讶的高水平 CD150，超过任何其他淋巴细胞亚群，包括中枢和效应记忆 T 细胞。此外，将 MAIT 细胞暴露于 MeV 会导致它们有效感染和快速凋亡。这构成了病毒病原体直接感染 MAIT 细胞的第一份报告。鉴于 MAIT 细胞的抗菌特性，它们被 MeV 清除可能会导致麻疹引起的免疫抑制和增加对无关感染的脆弱性。