Tick-borne encephalitis virus (TBEV) is a single-stranded, positive-sense RNA virus in the family Flaviviridae that is endemic in parts of Europe and Asia and can cause meningitis or encephalitis. Due to the disease severity, TBEV requires handling under heightened biosafety measures. The establishment and validation of inactivation procedures is a prerequisite for downstream analyses and management of occupational exposure. Therefore, different procedures for TBEV inactivation were tested. Our results suggest that TBEV is susceptible to inactivation by heat, acidic pH, different concentrations of alcohol, formaldehyde or detergents and exposure to UV irradiation, which may depend on sample size and composition.

中文翻译：

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蜱传脑炎病毒对热、酸性 pH 值、化学或紫外线处理灭活的敏感性。

蜱传脑炎病毒 (TBEV) 是黄病毒科中的一种单链正链 RNA 病毒，在欧洲和亚洲部分地区流行，可引起脑膜炎或脑炎。由于疾病的严重性，TBEV 需要在加强的生物安全措施下进行处理。灭活程序的建立和验证是职业暴露下游分析和管理的先决条件。因此，测试了不同的 TBEV 灭活程序。我们的结果表明 TBEV 容易因热、酸性 pH、不同浓度的酒精、甲醛或清洁剂以及暴露于紫外线照射而失活，这可能取决于样本大小和组成。