Aging and circadian rhythms are two biological processes that affect an organism, although at different time scales. Nevertheless, due to the overlap of their actions, it was speculated that both interfere or interact with each other. However, to address this question, a much deeper insight into these processes is necessary, especially at the cellular level. New methods such as single-cell RNA-sequencing (scRNA-Seq) have the potential to close this gap in our knowledge. In this review, we analyze applications of scRNA-Seq from the aging and circadian rhythm fields and highlight new findings emerging from the analysis of single cells, especially in humans or rodents. Furthermore, we judge the potential of scRNA-Seq to identify common traits of both processes. Overall, this method offers several advantages over more traditional methods analyzing gene expression and will become an important tool to unravel the link between these biological processes.

中文翻译：

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单细胞转录组学可以对衰老和昼夜节律过程提供新的见解。

衰老和昼夜节律是影响生物体的两个生物过程，尽管时间尺度不同。然而，由于他们的行动重叠，推测两者相互干扰或相互作用。然而，为了解决这个问题，需要更深入地了解这些过程，尤其是在细胞水平上。诸如单细胞 RNA 测序 (scRNA-Seq) 之类的新方法有可能弥合我们知识中的这一差距。在这篇综述中，我们分析了 scRNA-Seq 在衰老和昼夜节律领域的应用，并强调了单细胞分析中出现的新发现，尤其是在人类或啮齿动物中。此外，我们判断 scRNA-Seq 识别两个过程的共同特征的潜力。总体，