Abstract

Temperature affects animal physiology, including aging and lifespan. How temperature and biological systems interact to influence aging and lifespan has been investigated using model organisms, including the nematode Caenorhabditis elegans. In this review, we discuss mechanisms by which diverse cellular factors modulate the effects of ambient temperatures on aging and lifespan in C. elegans. C. elegans thermosensory neurons alleviate lifespan-shortening effects of high temperatures via sterol endocrine signaling and probably through systemic regulation of cytosolic proteostasis. At low temperatures, C. elegans displays a long lifespan by upregulating the cold-sensing TRPA channel, lipid homeostasis, germline-mediated prostaglandin signaling, and autophagy. In addition, co-chaperone p23 amplifies lifespan changes affected by high and low temperatures. Our review summarizes how external temperatures modulate C. elegans lifespan and provides information regarding responses of biological processes to temperature changes, which may affect health and aging at an organism level.

摘要

温度会影响动物生理，包括衰老和寿命。温度和生物系统如何相互作用以影响衰老和寿命已使用模型生物进行了研究，包括线虫秀丽隐杆线虫。在这篇综述中，我们讨论了各种细胞因子调节线粒体衰老和寿命对环境温度的影响的机制。秀丽隐杆线虫的热感觉神经元通过固醇内分泌信号传递和可能通过对胞质蛋白稳态的系统调节来减轻高温的寿命缩短作用。在低温下，秀丽隐杆线虫通过上调冷敏TRPA通道，脂质稳态，种系介导的前列腺素信号传导和自噬，可显示较长的寿命。此外，伴侣蛋白p23可以放大受高温和低温影响的寿命变化。我们的综述总结了外部温度如何调节秀丽隐杆线虫的寿命，并提供了有关生物过程对温度变化的响应的信息，温度变化可能会影响生物体水平上的健康和衰老。