Abstract

This study aims to provide the first brain structural-behavioral correlates underlying age differences in Grooved Pegboard Test (GPT) performance after adjusting for gender, education, quality of life, mental health, and anthropometric variables. We report the data of 210 right-handed participants (20- to 80-year old), who underwent behavioral assessments including GPT, Trail Making Test, and stop-signal task. Magnetic resonance images were acquired to investigate the structural-behavioral correlates of age differences in GPT performance. Age differences in GPT performance were positively associated with visuomotor tracking performance and negatively associated with widespread brain structural measures, including white matter tracts (e.g., commissure, radiation, and association fibers) and gray matter regions in frontal and cingulate regions, parietal, and temporal lobes.

摘要

本研究旨在提供第一个大脑结构行为相关性，在调整性别、教育、生活质量、心理健康和人体测量变量后，凹槽钉板测试 (GPT) 表现中的潜在年龄差异。我们报告了 210 名惯用右手的参与者（20 至 80 岁）的数据，他们接受了行为评估，包括 GPT、跟踪测试和停止信号任务。获取磁共振图像以研究 GPT 表现中年龄差异的结构行为相关性。GPT 表现的年龄差异与视觉运动追踪表现呈正相关，与广泛的大脑结构测量呈负相关，包括白质束（例如，连合、辐射和关联纤维）以及额叶和扣带回区的灰质区域，