ABSTRACT

This study examined the relationship between multiple chronic conditions (MCC) and risk of cognitive impairment with no dementia (CIND) and dementia among older Americans. A sample of 637 individuals aged 70 or older was drawn from the Aging, Demographics, and Memory Study, a supplementary dataset of the larger national Health and Retirement Study. Multinomial logistic regression analysis was conducted to investigate the association between MCC and cognition categorized as (a) no cognitive impairment, (b) CIND, or (c) dementia. Having MCC, particularly three or more chronic conditions, was significantly related to being diagnosed with CIND in our study, but not dementia. Our findings suggest that the presence of MCC may be a risk factor for cognitive impairment in later life. However, further investigation using a longitudinal design is needed to better understand the mechanism of how MCC may be related to CIND and dementia among older adults in the United States.

摘要

本研究调查了美国老年人的多种慢性病 (MCC) 与无痴呆 (CIND) 和痴呆的认知障碍风险之间的关系。从老龄化、人口统计和记忆研究中抽取了 637 名 70 岁或以上的人作为样本，这是更大的国家健康和退休研究的补充数据集。进行多项逻辑回归分析以研究 MCC 与分类为 (a) 无认知障碍、(b) CIND 或 (c) 痴呆症的认知之间的关联。在我们的研究中，患有 MCC，尤其是三种或更多种慢性疾病，与被诊断为 CIND 显着相关，但与痴呆症无关。我们的研究结果表明，MCC 的存在可能是晚年认知障碍的危险因素。然而，