Abstract

A novel series of Schiff base indolyl-pyridine derivatives containing, thiazolidinone and azetidinone moieties were synthesized. The structure of these recently integrated compounds was asserted by their IR, ¹H, ¹³C NMR, mass spectral data as well as elemental analysis. These compounds were likewise evaluated for in vitro antimicrobial, antioxidant, anti-TB and anticancer activities. The structure-activity relationships of compounds were also established. Among which compound 4a has dynamic bactericidal activity against S. aureus and B. subtilis, compound 5a applied extraordinary action against E. coli and K. pneumonia and fungicidal activities. Antioxidant studies revealed that 4c, 5 b and 5e showed noteworthy antioxidant activities. While, anticancer movement demonstrated that compound 4e was most strong toward all attempted cancer cell lines. Compound 5e apparently was generally powerful against H37Rv strain M. tuberculosis. Further, to understand the binding modes of the incorporated compounds molecular docking contemplates were performed using crystal structure of mycobacterium smegmat complexed with SQ109 (PDB ID: 6AJG, resolution: 2.604 Å).

摘要

合成了一系列含有噻唑烷酮和氮杂环丁酮部分的席夫碱吲哚基吡啶衍生物。这些最近整合的化合物的结构通过它们的 IR、¹ H、¹³ C NMR、质谱数据以及元素分析来确定。同样评估了这些化合物的体外抗微生物、抗氧化、抗结核和抗癌活性。还建立了化合物的构效关系。其中化合物4a对金黄色葡萄球菌和枯草芽孢杆菌具有动态杀菌活性，化合物5a对大肠杆菌和肺炎克雷伯菌具有非凡的杀菌作用和杀菌活性。抗氧化研究表明，4c、5b和5e显示出显着的抗氧化活性。同时，抗癌运动表明化合物4e对所有尝试的癌细胞系最强。化合物5e显然对 H37Rv 菌株M. tuberculosis普遍有效。此外，为了了解掺入化合物的结合模式，使用与 SQ109 复合的耻垢分枝杆菌晶体结构（PDB ID：6AJG，分辨率：2.604 Å）进行了分子对接设想。