ABSTRACT This investigation displays antioxidant potential of Cymbocarpum erythraeum essential oils and their biological effects like cytotoxic and anticholinesterase. The antioxidant capacities of the essential oils were estimated by DPPH, TBA, TOS assays. The anticholinesterase activity of essential oils was estimated utilizing Ellman method. The human U-87MG and PC-3 were handled and measurements were estimated by MTT test. The root essential oil showed high cytotoxic activity on PC-3 cells with 48.33% whereas aerial part essential oils indicated high cytotoxic activity on U-87MG cells with 34.62% at 0.03 mg/L. Root oil presented the highest acetylcholinesterase and butyrylcholinesterase inhibition (IC50: 113, 197 µM, respectively). The GC-FID and GC-MS assays showed that major components of aerial part with flowers and root oils were (E)-2-decenal (52.1%); (E)-2-dodecenal (36.1%), and (E)-2-tetradecenal (22.3%), respectively. (E)-2-dodecenal was a major compound of root il and exhibited AChE and BuChE inhibitory (IC50: 100, 136 µM, respectively) and antioxidant effects. Graphical Abstract

中文翻译：

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Cymbocarpum erythraeum (DC.) Boiss 精油的细胞毒性作用和分子对接研究。（伞形科）作为胆碱酯酶的潜在抑制剂

摘要 本研究显示了香茅精油的抗氧化潜力及其生物效应，如细胞毒性和抗胆碱酯酶。精油的抗氧化能力通过 DPPH、TBA、TOS 测定进行评估。精油的抗胆碱酯酶活性用 Ellman 方法估计。处理人类 U-87MG 和 PC-3，并通过 MTT 测试估计测量值。根精油对 PC-3 细胞的细胞毒活性为 48.33%，而地上部分精油对 U-87MG 细胞的细胞毒活性为 34.62%，浓度为 0.03 mg/L。根油表现出最高的乙酰胆碱酯酶和丁酰胆碱酯酶抑制作用（IC50 分别为 113、197 µM）。GC-FID和GC-MS分析表明，地上部分有花和根油的主要成分为(E)-2-癸烯醛(52.1%)；(E)-2-十二碳烯醛 (36.1%) 和 (E)-2-十四碳烯醛 (22.3%)，分别。(E)-2-十二烯醛是根 il 的主要化合物，具有 AChE 和 BuChE 抑制作用（IC50 分别为 100、136 µM）和抗氧化作用。图形概要