Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.

中文翻译：

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肌肉源性肌胶质蛋白调节果蝇成虫盘生长


器官的生长和大小由内在和外在信号分子精细调节。在果蝇中，BMP 家族成员 Dpp 在一组有限的成虫盘细胞中产生，并作为经典的形态发生素通过在整个成虫盘中扩散来调节模式和生长。然而，TGFβ/激活素样配体在椎间盘生长控制中的作用仍然不明确。在这里，我们证明肌胶质蛋白 (Myo) 是激活素家族成员，也是哺乳动物肌生长抑制素 (Mstn) 的密切同源物，是一种肌肉来源的外在因子，它使用典型的 dSmad2 介导的信号传导来调节翅膀大小。我们认为，Myo 是一种肌因子，有助于调节肌肉及其相关附肢之间的异速生长关系。