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Three‐component reaction for synthesis of 2‐amino‐6‐aryl‐5‐(phenylamino)‐3,7‐dihydro‐4H‐pyrrolo[2,3‐d]pyrimidin‐4‐one derivatives in water
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-07 , DOI: 10.1002/jhet.4042
Xiaopeng Yang 1 , Chunmei Li 1 , Chenze Qi 1 , Furen Zhang 1
Affiliation  

A new three‐component domino reaction for the synthesis of 2‐amino‐6‐aryl‐5‐(phenylamino)‐3,7‐dihydro‐4H‐pyrrolo[2,3‐d]pyrimidin‐4‐one derivatives 4 using acetic acid as catalyst has been established. The reaction was performed in aqueous media using readily available and inexpensive 2,6‐diaminopyrimidin‐4(3H)‐one 1, 2,2‐dihydroxy‐1‐arylethan‐1‐one 2 and aniline 3 as substrates. The simple and efficient one‐pot three‐component approach, inexpensive catalyst, green reaction media, make the present methodology a good synthetic procedure.

中文翻译:

在水中合成2-氨基-6-芳基-5-(苯氨基)-3,7-二氢-4H-吡咯并[2,3-d]嘧啶-4-酮衍生物的三组分反应

对于2-氨基-6-芳基-5-(苯基氨基)合成的新三组分多米诺反应-3,7-二氢-4- ħ吡咯并[2,3- d ]嘧啶-4-酮衍生物4使用已经建立了乙酸作为催化剂。将反应物使用容易获得且廉价的在含水介质中进行的2,6-二氨基嘧啶4(3 ħ) -酮1,2,2-二羟基-1- arylethan -1-酮2和苯胺3作为底物。简单有效的一锅三组分方法,廉价的催化剂,绿色反应介质使本方法成为一种良好的合成方法。
更新日期:2020-09-08
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